Seresto Collar & Advantix: Can You Use Them Together for Maximum Flea & Tick Protection?

By Kasim Kittiban 12 Min Read
Seresto Collar & Advantix: Can You Use Them Together for Maximum Flea & Tick Protection?

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When protecting your four-legged family members from pests, deciding which products to use can be tricky. Among the most popular options are Seresto collars and Advantix flea and tick preventative.

While they are both effective in repelling unwanted pests, many pet owners ask, “Can I use Seresto collar and Adventix together?” The answer is NO. You may use one after the other, following a specific guideline. However, combining them is not suggested.

This article explains everything about these two products and why they are not recommended to be used together. 

Here’s all you need to know,

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Seresto Collar – Uses and Benefits

The Seresto collar is an insecticide collar for dogs and cats that provides long-lasting protection against fleas, ticks, and other pests. 

It consists of a polymer matrix that releases a low dose of active ingredients, imidacloprid, and flumethrin, over an extended period through the skin and fur of the animal.

The active ingredients spread from direct contact over the skin surface, providing practical and long-lasting protection.

The Seresto collar is easy to use; simply place it around your pet’s neck and adjust it for a comfortable fit. It is also water-resistant and remains effective even after exposure to water.

Some other benefits of using the Seresto collar include the following:

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  • Convenient and long-lasting protection: The collar provides up to 8 months of protection for dogs and up to 7 months for cats, reducing the need for frequent treatments.
  • Effective against a wide range of pests: The collar is effective against fleas, ticks, lice, and mosquitoes, helping to keep your pet protected from a variety of pests.
  • Safe for pets: The Seresto collar has been extensively tested for dogs and cats, making it a convenient and practical choice for pet owners.

Advantix – Uses and Benefits 

Advantix is a topical flea and ticks treatment for dogs. It is a liquid applied straight to the dog’s neck’s back skin. The active ingredients in Advantix are imidacloprid and permethrin.

Some benefits of using Advantix include the following:

  • Effective against a wide range of pests: Advantix is effective against fleas, ticks, mosquitoes, and other pests, providing comprehensive protection for your dog.
  • Fast-acting: Advantix begins to work quickly, killing fleas within hours of application and providing protection against ticks within 48 hours.
  • Long-lasting: Advantix provides up to 4 weeks of protection against fleas and ticks, reducing the need for frequent reapplication.
  • Easy to use: Advantix is simple and comes with a handy squeeze-on applicator that delivers the medication to your dog’s skin.

However, it is recommended to use Advantix as directed and to consult with your veterinarian before using it on dogs with pre-existing medical conditions or on dogs that are taking certain medications.

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  • Safe for dogs: Advantix has been extensively tested when used as directed.

Note: Advantix is not recommended for cats, as it can be toxic to felines.

Compatibility of Seresto Collar and Advantix 

Using the Seresto collar and Advantix topical treatment together on the same animal is not recommended.

Advantix is a topical treatment applied directly to the skin, while Seresto is a collar worn around the neck. 

Combining these two products may increase the risk of adverse reactions, including skin irritation and toxicity.

It is primarily due to the cause of both products containing insecticides, leading to an overdose of the active ingredients and increasing the risk of side effects.

However, speaking with your veterinarian before using the Seresto collar and Advantix simultaneously is crucial.

They will be able to provide you with the best advice based on your dog’s individual needs and health status, as well as advise you on the best flea and tick prevention and treatment plan for your pet.

Seresto Collar & Advantix – Side Effects

The Seresto collar and Advantix can cause side effects in some dogs, although these are typically mild and short-lived. Common side effects of the Seresto collar and Advantix include:

  • Skin irritation or itching at the site of application
  • Bruising or redness where the application was made
  • Loss of hair or hair discoloration at the site of application
  • Vomiting
  • Diarrhea
  • Lethargy or decreased appetite
  • Seizures (in rare cases)

Call your vet immediately if your dog encounters any of these negative effects. Rarely, more serious side effects may appear and necessitate veterinarian care.

It is essential to follow the instructions and use the Seresto collar and Advantix as directed and to consult with your veterinarian before using them on dogs with pre-existing medical conditions or on dogs that are taking certain medications.

Why Is Flea and Tick Prevention Important?

Flea and tick prevention is important in keeping your dog healthy and comfortable. Fleas are the leading cause of tapeworm, a parasite whose larvae are carried by fleas, so it’s important to take steps to prevent them from infesting your pet.

Dr. Andrea Tu of Park East Animal Hospital in New York City recommends regularly running a flea comb throughout your dog’s coat to check for fleas and look out for “flea dirt” – little black specks usually found on a dog’s belly or around the tail. 

Ticks can also transmit serious conditions such as Lyme disease, Rocky Mountain Spotted Fever, Ehrlichiosis, and Anaplasmosis, so take steps to keep them away from your pet as well.

Seresto Collar and Advantix – Which is Safest? 

In terms of safety, the Seresto collar may be slightly safer than Advantix as it releases a lower dose of active ingredients over a more extended period, reducing the risk of toxicity.

Additionally, Seresto Collar is a non-greasy collar that slowly releases an insecticide through the pet’s coat. It can last up to 8 months and is water-resistant, making it a convenient option for pet owners.

Advantix, on the other hand, can be toxic to aquatic life if your pet swims in the ocean, so it’s essential to thoroughly rinse your pet after swimming in any body of water.

However, it is essential to note that the safety of the Seresto collar and Advantix will depend on several factors, including the size and breed of your dog, any pre-existing medical conditions they may have, and any other medications.

It’s also essential to follow the instructions on the product label and observe your pet for any adverse reactions after use.


it is not recommended to use Seresto collars and Advantix together. If you are using a Seresto collar, it is best to stick with it alone to ensure your pet is as safe and healthy as possible.

However, if you need to use both products, it is best to consult your vet. That’s because, according to expert vets, both products contain similar ingredients, so using them simultaneously can lead to an overdose of active ingredients.

As a result, it can cause adverse side effects and potentially harm the pet. Thus, consult a veterinarian to determine your pet’s most appropriate flea and tick prevention method.


Can you use a Seresto collar with Advantix II?

Seresto collars and Advantix II protect against flea and tick infestations, but they should not be used together.

Seresto collars contain an active ingredient called imidacloprid and a second active ingredient called flumethrin, which work together to provide broad-spectrum protection against fleas and ticks.

Advantix II contains an active ingredient called imidacloprid but does not contain the second active ingredient, flumethrin.

Therefore, combining the two products may lessen their respective efficacy. 

Can you use Advantix and a flea collar at the same time?

Using Advantix and a flea collar at the same time can effectively combat fleas and ticks in pets.

Advantix is a topical medication applied to the pet’s skin and can repel and kill fleas, ticks, and mosquitoes.

A flea collar releases a chemical absorbed into the pet’s skin, killing and repelling fleas and ticks.

When used together, Advantix and a flea collar can provide extra protection for the pet.

Can you use advantage and Seresto collars together?

Using Advantage and Seresto collars together is not recommended, as the two products may not be compatible. The two collars contain different active ingredients, which may interact with each other and cause irritation to the pet.

Can you use topical flea treatment with a Seresto collar?

Yes, but it is essential to take certain precautions. For example, the Seresto collar should be put on the pet first, and then the topical treatment should be applied at least 24 hours later.

Additionally, it is essential to read the instructions on the topical flea product to ensure that it is compatible with the Seresto collar.

Using proper precautions, a Seresto collar and topical flea treatment can ensure that your pet is effectively protected from fleas and ticks.

Is Advantix safer than Seresto?

Seresto is often recommended as being slightly safer than Advantix.

Advantix contains a pesticide, imidacloprid, which can be harmful if ingested in large doses. Seresto, on the other hand, is a collar designed to be safer than traditional flea and tick topicals—it contains a chemical, flumethrin, that binds to the plastic of the collar and is released in small doses.

While both Advantix and Seresto are effective and generally safe, Seresto is often the safer option.

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Kasim is a highly knowledgeable and passionate animal lover who has devoted much of his life to the care and well-being of dogs. As an avid supporter of all Doodle dog breeds, Kasim has extensive expertise in their care and behavior. He owns his own Golden Doodle and has volunteered at the Humane Society for many years, fostering dogs and helping animals in need. Kasim's dedication to the welfare of dogs has led him to become a respected authority in the field of Doodle care and training. He frequently writes articles and provides free advice to Doodle owners everywhere, sharing his knowledge and expertise with others. Kasim's deep understanding of Doodle behavior and temperament, as well as his passion for animal welfare, make him a trusted and reliable source of information. In addition to his own experience as a Doodle owner and volunteer, Kasim is also knowledgeable about the breeding and care of these beloved dogs. He regularly speaks with dog breeders and stays up to date with the latest research and best practices in Doodle care. Kasim's comprehensive knowledge of Doodle dogs and his dedication to their well-being make him a valuable resource for anyone looking to learn more about these beloved pets.