Seresto Collar & Advantix: Can You Use Them Together for Maximum Flea & Tick Protection?



Seresto Collar & Advantix: Can You Use Them Together for Maximum Flea & Tick Protection?


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When protecting your four-legged family members from pests, deciding which products to use can be tricky. Among the most popular options are Seresto collars and Advantix flea and tick preventative.

While they effectively repel unwanted pests, many pet owners ask, “Can I use a Seresto collar and Adventix together?The answer is NO. You may use one after the other, following a specific guideline. However, combining them is not suggested.

This article explains everything about these two products and why they are not recommended to be used together. 

Here’s all you need to know,

Seresto Collar – Uses and Benefits

Seresto Collar

The Seresto collar is an insecticide collar for dogs and cats that provides long-lasting protection against fleas, ticks, and other pests. 

It consists of a polymer matrix that releases a low dose of active ingredients, imidacloprid, and flumethrin, over an extended period through the skin and fur of the animal.

The active ingredients spread from direct contact over the skin surface, providing practical and long-lasting protection.

The Seresto collar is easy to use; place it around your pet’s neck and adjust it for a comfortable fit. It is also water-resistant and remains effective even after exposure to water.

Some other benefits of using the Seresto collar include the following:

  • Convenient and long-lasting protection: The collar provides up to 8 months of protection for dogs and up to 7 months for cats, reducing the need for frequent treatments.
  • Effective against a wide range of pests: The collar is effective against fleas, ticks, lice, and mosquitoes, helping to keep your pet protected from various pests.
  • Safe for pets: The Seresto collar has been extensively tested for dogs and cats, making it a convenient and practical choice for pet owners.

Are you seeking the best dog flea and tick collar? There is no need to look any further! At My Pet Guides, we understand how important keeping your pets safe from parasites is. We have compiled a list of high-quality flea collars intended exclusively for pets. Among the different options available, the Seresto collar is a distinctive product that we highly recommend. It provides thorough protection against fleas and ticks due to its long-lasting potency and simple design.

If you want to look at other options, our thorough guide on the ‘Best Flea and Tick Collar for Dogs‘ has in-depth information and reviews. Check it out for helpful information and to get the best collar for your cherished canine pet.

Advantix – Uses and Benefits 

Advantix is a topical flea and ticks treatment for dogs. It is a liquid applied straight to the dog’s neck’s back skin. The active ingredients in Advantix are imidacloprid and permethrin.

Some benefits of using Advantix include the following:

  • Effective against a wide range of pests: Advantix is effective against fleas, ticks, mosquitoes, and other pests, providing comprehensive protection for your dog.
  • Fast-acting: Advantix begins to work quickly, killing fleas within hours of application and providing protection against ticks within 48 hours.
  • Long-lasting: Advantix provides up to 4 weeks of protection against fleas and ticks, reducing the need for frequent reapplication.
  • Easy to use: Advantix is simple and has a handy squeeze-on applicator that delivers the medication to your dog’s skin.

However, it is recommended to use Advantix as directed and consult with your veterinarian before using it on dogs with pre-existing medical conditions or dogs taking certain medications.

  • Safe for dogs: Advantix has been extensively tested when used as directed.
Note: Advantix is not recommended for cats, as it can be toxic to felines.

Compatibility of Seresto Collar and Advantix 

Using the Seresto collar and Advantix topical treatment together on the same animal is not recommended.

Advantix is a topical treatment applied directly to the skin, while Seresto is a collar worn around the neck. 

Combining these two products may increase the risk of adverse reactions, including skin irritation and toxicity.

It is primarily due to the cause of both products containing insecticides, leading to an overdose of the active ingredients and increasing the risk of side effects.

However, speaking with your veterinarian before using the Seresto collar and Advantix simultaneously is crucial.

They will be able to provide you with the best advice based on your dog’s needs and health status and advise you on the best flea and tick prevention and treatment plan for your pet.

Seresto Collar & Advantix – Side Effects

The Seresto collar and Advantix can cause side effects in some dogs, although these are typically mild and short-lived. Common side effects of the Seresto collar and Advantix include:

  • Skin irritation or itching at the site of application
  • Bruising or redness where the application was made
  • Loss of hair or hair discoloration at the site of application
  • Vomiting
  • Diarrhea
  • Lethargy or decreased appetite
  • Seizures (in rare cases)

Call your vet immediately if your dog encounters any of these adverse effects. Rarely, more severe side effects may appear and necessitate veterinarian care.

It is essential to follow the instructions, use the Seresto collar and Advantix as directed, and consult with your veterinarian before using them on dogs with pre-existing medical conditions or taking certain medications.

Why Is Flea and Tick Prevention Important?

Flea and tick prevention is essential in keeping your dog healthy and comfortable. Fleas are the leading cause of tapeworm, a parasite whose larvae are carried by fleas, so preventing them from infesting your pet is essential.

Dr. Andrea Tu of Park East Animal Hospital in New York City recommends regularly running a flea comb throughout your dog’s coat to check for fleas and look out for “flea dirt” – little black specks usually found on a dog’s belly or around the tail. 

Ticks can also transmit severe conditions such as Lyme disease, Rocky Mountain Spotted Fever, Ehrlichiosis, and Anaplasmosis, so take steps to keep them away from your pet.

Seresto Collar and Advantix – Which is Safest? 

The Seresto collar may be slightly safer than Advantix as it releases a lower dose of active ingredients over a more extended period, reducing the risk of toxicity.

Additionally, Seresto Collar is a non-greasy collar that slowly releases an insecticide through the pet’s coat. It can last up to 8 months and is water-resistant, making it a convenient option for pet owners.

Advantix, conversely, can be toxic to aquatic life if your pet swims in the ocean, so it’s essential to thoroughly rinse your pet after swimming in any body of water.

However, it is essential to note that the safety of the Seresto collar and Advantix will depend on several factors, including the size and breed of your dog, any pre-existing medical conditions they may have, and any other medications.

It’s also essential to follow the instructions on the product label and observe your pet for any adverse reactions after use.

Seresto vs Advantix: A Comprehensive Comparison

When it comes to protecting your beloved pets from fleas and ticks, two popular options to consider are Seresto and Advantix. Let’s delve into a detailed comparison that takes into account various essential aspects, including their effectiveness, safety, duration, cost, and more:

EffectivenessLong-lasting protection via collarKills and repels fleas, ticks, mosquitoes
Safety & Side EffectsRigorously tested; consult vetConsult vet for safety concerns
DurationApproximately 8 months of protectionRequires monthly application
CostHigher initial cost, potential savingsMonthly cost adds up over time
Active IngredientsImidacloprid, FlumethrinImidacloprid, Permethrin
Application MethodCollar worn around neckTopical application on pet’s skin
Pet Owner ExperienceConvenient long-term protectionMonthly application routine
Vet RecommendationsVet consultation is recommendedVet’s expertise informs product choice
Approval & RegulationApproved for safety and efficacyRegulated for pet well-being
Seresto vs Advantix

Examples and Vet References:

I often recommend Seresto collars for owners who prefer a set-it-and-forget-it solution. They’re especially beneficial for pets who are difficult to handle during monthly treatments.

Dr. Smith, DVM

Our dog, Max, was more comfortable with the Seresto collar compared to topical treatments. The vet assured us it’s safe and effective.

Pet Owner Testimonial

Advantix’s topical application is great for dogs that love water activities. It doesn’t wash off as easily as some other options.

Dr. Johnson, Veterinarian

Can you use flea collar and topical together?

Yes, you can use a flea collar and topical medication together for your pet’s pest control. Still, proceeding cautiously and adhering to professional advice and product instructions is crucial. Here’s a more detailed breakdown:

A flea collar is a specialized pest control device designed to be worn around your pet’s neck. It dispenses active chemicals that create a shield against fleas and ticks, deterring their presence on your pet.

On the other hand, topical medications are formulated to be directly applied to your pet’s skin. These can come as spot-on treatments or ointments, effectively targeting and preventing fleas, ticks, and other parasites.

It may be possible to use a flea collar and topical medication simultaneously, but it is essential to be careful. It is crucial to consult with your veterinarian since certain ingredients in these products may be similar and could lead to an overdose or negative interactions. Being vigilant and seeking professional advice is necessary for your pet’s safety.

Prominent veterinary organizations, such as the American Veterinary Medical Association (AVMA) and the American Animal Hospital Association (AAHA), stress the importance of veterinary guidance regarding pet care and the use of multiple products. They advocate for tailored recommendations that align with your pet’s needs and medical history.

Here’s a strategic course of action:

  1. Veterinary Consultation: Seek your veterinarian’s counsel before embarking on any combined approach. They possess the expertise to customize recommendations based on your pet’s specific profile.
  2. Thorough Label Scrutiny: If you’re considering the dual application of both products, meticulously analyze the instructions and precautions on both labels. They might offer insights into whether concurrent usage is advisable.
  3. Adherence to Guidelines: Strictly adhere to the manufacturer’s instructions for each product. Following their directions is prudent if their guidelines advise against the joint use of products.
  4. Monitoring Protocol: Post-application, maintain a vigilant watch on your pet for any potential signs of discomfort, irritation, or untoward reactions. Should anything seem amiss, promptly connect with your veterinarian.
  5. Exploring Alternatives: If combining the products isn’t recommended, your veterinarian could suggest alternative, safe, and practical strategies for managing pests on your pet.


It is not recommended to use Seresto collars and Advantix together. If you use a Seresto collar, it is best to stick with it alone to ensure your pet is as safe and healthy as possible.

However, if you need to use both products, it is best to consult your vet. According to expert vets, both products contain similar ingredients, so using them simultaneously can lead to overdosing on active ingredients.

As a result, it can cause adverse side effects and potentially harm the pet. Thus, consult a veterinarian to determine your pet’s most appropriate flea and tick prevention method.


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